Positive Correlation of RANK Expression on Human Monocytes with Age: RANK Expressed on Human Monocytes may play a Role in Senile Osteoporosis
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چکیده
منابع مشابه
Follicle-stimulating hormone promotes RANK expression on human monocytes.
Elevated serum concentrations of follicle-stimulating hormone (FSH) are associated with diminished bone density in women, beginning years before menopause and the decline in estradiol. We hypothesized that FSH promotes development of myeloid cells toward the bone-resorbing osteoclast phenotype. This was tested by isolating peripheral blood mononuclear cells from nine healthy adults, incubating ...
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Rheumatoid arthritis (RA) appears as inflammation of synovial tissue and joint destruction. Receptor activator of NF-κB (RANK) is a member of the TNF receptor superfamily and a receptor for the RANK ligand (RANKL). In this study, we examined the expression of RANKhigh and CCR6 on CD14+ monocytes from patients with RA and healthy volunteers. Peripheral blood samples were obtained from both the R...
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DNA methylation is one of several epigenetic mechanisms that contribute to the regulation of gene expression; however, the extent to which methylation of CpG dinucleotides correlates with gene expression at the genome-wide level is still largely unknown. Using purified primary monocytes from subjects in a large community-based cohort (n = 1264), we characterized methylation (>485 000 CpG sites)...
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ژورنال
عنوان ژورنال: Journal of Osteoporosis and Physical Activity
سال: 2017
ISSN: 2329-9509
DOI: 10.4172/2329-9509.1000193